Sindhu took just 33 minutes to get the better of American Lauren Lam 21-16 21-13
Former world No. 1 Saina, who missed a lot of tournaments last year due to multiple injuries, moved to the second round after her opponent, Czech Republic's Tereza Svabikova, suffered a back injury and retired mid-way while trailing 20-22, 0-1 in an opening round match.
The other men's singles semi-final match on Saturday will be played between Priyanshu Rajawat and Kaushal Dharmamer.
Besides Srikanth, the other players withdrawn are Ashwini Ponnappa, Ritika Rahul Thkar, Treesa Jolly, Mithun Manjunath, Simran Aman Singh and Khushi Gupta.
Star Indian shuttlers PV Sindhu and Kidambi Srikanth will look to arrest their slump in form when they begin their campaign at the Australia Open badminton tournament in Sydney on Tuesday.
On Wednesday, Commonwealth Games bronze medallists Ashwini Ponnappa and N Sikki Reddy, seeded eighth, scraped past the Denmark duo of Amalie Magelund and Freja Ravn 21-9, 17-21, 21-19 in the women's doubles.
Two players withdrawn from India Open due to COVID-19
Fresh from their Korea Open triumph, Satwiksairaj Rankireddy and Chirag Shetty will look to continue their dream run.
Injured HS Prannoy's absence hurt India as they went down fighting 2-3 against badminton powerhouse China
20-year-old Malvika Bansod, ranked 111th, took 34 minutes to register a straight games victory against former World No 1 Saina Nehwal.
Saina had pulled out of the opening round of All England Open Championships last week after suffering a thigh injury.
Services remained on top of the medal table with 41 gold, 28 silver and 26 bronze for a total of 95. Haryana won four of the five gold medals in archery to consolidate their second place with 29 gold.
Saina showed signs of regaining her form on her way to a sensational win over Chinese world number 9 He Bing Jiao
Summary of sports events and persons who made news on Thursday
Top shuttlers Ashwini Ponnappa and Lakshya Sen are among 20-odd Indian players who have started training at the Prakash Padukone Badminton Academy (PPBA) in Bengaluru as the sport took its first step towards resumption after the COVID-19 hiatus. Confined to their homes for more than two months due to the nationwide lockdown to contain the health crisis, the shuttlers started training at PPBA after the Sports Authority of India (SAI) laid down rules for resumption of training late last month.
A summary of sports events and persons who made news on Tuesday
The 30-year-old Indian shuttler had an impressive run in the $75,000 BWF Tour Super 100 tournament before caving in tamely 14-21, 10-21 to Shesar in 28 minutes.
A summary of sports events and persons who made news on Thursday
India's number one singles player Prajnesh Gunneswaran beat Jay Clarke of Great Britain in straight sets to enter the main draw of the Miami Open, on Wednesday.
A summary of sports events and persons who made news on Friday.
Summary of sports events and persons who made news on Saturday